Table 1 110 mutations in exon 9, 11, 13 or 17 of KIT were identified in 257 of 346 primary GISTs
From: Loss of PI3 kinase association improves the sensitivity of secondary mutation of KIT to Imatinib
Mutation frequency | Mutations |
|---|---|
29 | W557K558del |
25 | A502Y503dup |
19 | V559D |
17 | V560D |
7 | D579del, V560del |
6 | W557R |
5 | K642E |
4 | 557_561del, V559A, V559G, L576P, 574_586dup |
3 | 550_558del, 551_556del, 552_553del, 552_557del, W557C/558_560 del, 558_562del, 564_576del, 569_576del |
2 | 551_555del, 553_556del, 554_556del, 555_573del, 556_560del, K558I/V559del, V559del, 559_561del, V560G |
1 | K550L/551_560del, 550_554del, 550_556del, 550_557del/I558L559ins, 550_557del/K558G, P551L/M552del, 551_554del, M552K/553_556del, 552_558del, 552_570del, 552_570del/571insI, Y553N, Y553L/554_558del, 553_558del, 553_559del, E554D/555_560del, E554K/555_560del, 554_555del, V555del/Q556E, 555_556del, 555_559del, 555_560del/561insT, 555_571del, Q556V/W557T/558_559del, Q556H/557_560del, Q556H/557_572del, 556_557del/K558N, 556_560del/561insH, 556_569dup, 556_572del, 556_572del/573insH, 556_574del, W557G, W557F/K558Q, W557S/558_573del, W557T/558_563del, 557_558del/559insCE, 557_559del/V560F, 557_560del, 557_561del/562insFP, 557_564del, 557_574del, 557_559del/560insF, K558Q/V559P, K558R/559_564del, K558R/559_565del, K558del/559insNP, 558_559del, 558_559del/V560I, 558_564del, V559I, 559_560del, 559_568del/569insD, 560_576del, V560D/L576F, 561_575dup, 562_573del, 563_572del, 563_574del/575insGGGTCC, N567S, 567_573del, 572_577dup, 572_580dup, 572_583dup, 572_584dup, 573_578dup, 573_589dup, 574_580del, 574_585dup, 574_587dup, 574_591/591insA, Q575dup/L576V, 575_586dup, 576_586dup, 577_589dup, 577_591dup, 579_582dup/F584N, 579_587dup, 579_591dup, N822K |