Fig. 1
From: ATM, ATR and DNA-PKcs kinases—the lessons from the mouse models: inhibition ≠ deletion
The domain structure and the conserved catalytic loop of PI3KKs. a The catalytic loop in the kinase domain, with the conserved aspartate (D) residue depicted in blue, is reported for ATM, DNA-PKcs, ATR, mTOR and PK3CA. The location of the D residue in the mouse (m) and human (h) proteins is also indicated. b Structural domain organizations of PI3KKs ATM, DNA-PKcs and ATR, with underlined amino acid positions. The number of amino acids in the mouse full length proteins, and corresponding human in brackets, is indicated