Fig. 2

Schematic diagram showing the effect of dePARylation inhibitors on DDR. A damaged (star) DNA is shown on the top. PARP proteins (PARP1/2) are recruited to the site where they undergo PARylation and MARylation. The PAR/MAR moieties recruit DDR proteins to the vicinity of the damaged site. DePARylation (i.e. by PARG) digests the PAR chains, relives the PARP proteins and loads the DDR on the damaged site. DePARylation inhibitors trap the DDR on the PAR chains thereby preventing DDR and leading to cell death