Fig. 1From: H3K36me3, message from chromatin to DNA damage repairReduction of H3K36me3 leads to tumorigenesis. Cells with the SETD2 mutation show reduced H3K36me3 and DSR deficiency. H3G34R/V mutation and H3K36M mutation can inhibit the enzymatic activity of SETD2 to reduce the H3K36me3 in cellsBack to article page