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Fig. 5 | Cell & Bioscience

Fig. 5

From: STAT3 plays an important role in DNA replication by turning on WDHD1

Fig. 5

Overexpression of WDHD1 rescued DNA replication reduction induced by STAT3 knocking down. a After thymidine block and siRNA transfection, MCF-7 cells were released, transfected with WDHD1 plasmid, stained with BrdU and analyzed by flow cytometry. a representative experiment of 3 was shown (Upper panel). The stability of STAT3 and WDHD1 was monitored by immunoblotting analyses (Middle panel). Data were summarized (Lower panel). b Proposed model. STAT3 binds to the promoter/regulatory region of WDHD1, turns on its transcription. WDHD1 in turn participates DNA replication

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