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Table 6 Hemodynamic indicators of mice after inhibition of HDAC3 and miR-18a and overexpression of ADRB3

From: The crosstalk of HDAC3, microRNA-18a and ADRB3 in the progression of heart failure

Group\parameter

LVSP (mm Hg)

LEVDP (mm Hg)

dp/dt (mm Hg/s)

-dp/dt(mm Hg/s)

HF + sh-NC

78.87 ± 8.94

19.97 ± 2.14

6815.39 ± 545.34

5739.87 ± 877.31

HF + sh-HDAC3

98.69 ± 13.58 *

11.83 ± 1.57 *

9223.98 ± 987.21 *

9622.24 ± 696.58 *

HF + sh-HDAC3 + NC-antagomir

106.78 ± 18.56

12.56 ± 1.03

9552.43 ± 790.42

9301.86 ± 917.94

HF + sh-HDAC3 + miR-18a-antagomir

85.61 ± 7.07 #

18.37 ± 2.54 #

6998.23 ± 755.53 #

5696.38 ± 386.52 #

HF + sh-HDAC3 + oe-NC

99.78 ± 14.06

10.84 ± 1.28

9467.76 ± 876.82

9805.54 ± 817.53

HF + sh-HDAC3 + oe-ADRB3

81.42 ± 7.68 &

21.62 ± 2.79 &

6724.83 ± 545.39&

5443.52 ± 786.02 &

  1. * p < 0.05 vs. HF mice treated with sh-NC. # p < 0.05 vs. HF mice treated with sh-HDAC3 + NC-antagomir. & p < 0.05 vs. HF mice treated with sh-HDAC3 + oe-NC. One-way ANOVA was utilized for comparisons among multiple groups, and Tukey’s post-hoc test was employed for intra-group pairwise comparison