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Table 6 Hemodynamic indicators of mice after inhibition of HDAC3 and miR-18a and overexpression of ADRB3

From: The crosstalk of HDAC3, microRNA-18a and ADRB3 in the progression of heart failure

Group\parameter LVSP (mm Hg) LEVDP (mm Hg) dp/dt (mm Hg/s) -dp/dt(mm Hg/s)
HF + sh-NC 78.87 ± 8.94 19.97 ± 2.14 6815.39 ± 545.34 5739.87 ± 877.31
HF + sh-HDAC3 98.69 ± 13.58 * 11.83 ± 1.57 * 9223.98 ± 987.21 * 9622.24 ± 696.58 *
HF + sh-HDAC3 + NC-antagomir 106.78 ± 18.56 12.56 ± 1.03 9552.43 ± 790.42 9301.86 ± 917.94
HF + sh-HDAC3 + miR-18a-antagomir 85.61 ± 7.07 # 18.37 ± 2.54 # 6998.23 ± 755.53 # 5696.38 ± 386.52 #
HF + sh-HDAC3 + oe-NC 99.78 ± 14.06 10.84 ± 1.28 9467.76 ± 876.82 9805.54 ± 817.53
HF + sh-HDAC3 + oe-ADRB3 81.42 ± 7.68 & 21.62 ± 2.79 & 6724.83 ± 545.39& 5443.52 ± 786.02 &
  1. * p < 0.05 vs. HF mice treated with sh-NC. # p < 0.05 vs. HF mice treated with sh-HDAC3 + NC-antagomir. & p < 0.05 vs. HF mice treated with sh-HDAC3 + oe-NC. One-way ANOVA was utilized for comparisons among multiple groups, and Tukey’s post-hoc test was employed for intra-group pairwise comparison