Skip to main content

Table 4 Hemodynamic indicators in mice after alteration of ADRB3 and overexpression of miR-18a

From: The crosstalk of HDAC3, microRNA-18a and ADRB3 in the progression of heart failure

Group\parameter

LVSP (mm Hg)

LEVDP (mm Hg)

dp/dt (mm Hg/s)

dp/dt (mm Hg/s)

HF + sh-NC

81.56 ± 8.94

19.02 ± 2.14

6587.94 ± 545.34

5253.77 ± 667.49

HF + sh-ADRB3

118.69 ± 10.78 *

11.84 ± 1.07*

9453.73 ± 787.51 *

9982.83 ± 940.21 *

HF + miR-18a-agomir + oe-NC

113.78 ± 18.06

12.61 ± 1.44

9632.01 ± 810.12

9791.16 ± 917.24

HF + miR-18a-agomir + oe-ADRB3

95.61 ± 8.08 #

18.37 ± 2.09 #

6964.48 ± 545.33 #

5723.26 ± 346.42 #

  1. * p < 0.05 vs. HF mice treated with sh-NC. # p < 0.05 vs. HF mice treated with miR-18a-agomir + oe-NC. One-way ANOVA was utilized for comparisons among multiple groups, and Tukey’s post-hoc test was employed for intra-group pairwise comparison