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Table 4 Hemodynamic indicators in mice after alteration of ADRB3 and overexpression of miR-18a

From: The crosstalk of HDAC3, microRNA-18a and ADRB3 in the progression of heart failure

Group\parameter LVSP (mm Hg) LEVDP (mm Hg) dp/dt (mm Hg/s) dp/dt (mm Hg/s)
HF + sh-NC 81.56 ± 8.94 19.02 ± 2.14 6587.94 ± 545.34 5253.77 ± 667.49
HF + sh-ADRB3 118.69 ± 10.78 * 11.84 ± 1.07* 9453.73 ± 787.51 * 9982.83 ± 940.21 *
HF + miR-18a-agomir + oe-NC 113.78 ± 18.06 12.61 ± 1.44 9632.01 ± 810.12 9791.16 ± 917.24
HF + miR-18a-agomir + oe-ADRB3 95.61 ± 8.08 # 18.37 ± 2.09 # 6964.48 ± 545.33 # 5723.26 ± 346.42 #
  1. * p < 0.05 vs. HF mice treated with sh-NC. # p < 0.05 vs. HF mice treated with miR-18a-agomir + oe-NC. One-way ANOVA was utilized for comparisons among multiple groups, and Tukey’s post-hoc test was employed for intra-group pairwise comparison