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Table 3 Echocardiographic results of mice after alteration of ADRB3 and overexpression of miR-18a

From: The crosstalk of HDAC3, microRNA-18a and ADRB3 in the progression of heart failure

Group\parameter LVPWD (mm) IVSD (mm) LVEDD (mm) LVESD (mm) LVEF (%) LVFS (%)
HF + sh-NC 1.26 ± 0.14 0.74 ± 0.08 4.57 ± 0.58 3.87 ± 0.49 15.33 ± 1.01 15.13 ± 1.23
HF + sh-ADRB3 1.75 ± 0.19* 0.51 ± 0.07* 3.70 ± 0.31* 2.83 ± 0.21 * 23.48 ± 2.01* 24.13 ± 2.54*
HF + miR-18a-agomir + oe-NC 1.84 ± 0.17 0.57 ± 0.06 3.54 ± 0.31 2.66 ± 0.24 24.83 ± 1.59 26.32 ± 2.28
HF + miR-18a-agomir + oe-ADRB3 1.31 ± 0.08# 0.82 ± 0.09 # 4.37 ± 0.50 # 3.67 ± 0.42 # 15.99 ± 2.34 # 16.21 ± 1.14 #
  1. * p < 0.05 vs. HF mice treated with sh-NC. # p < 0.05 vs. HF mice treated with miR-18a-agomir + oe-NC. One-way ANOVA was utilized for comparisons among multiple groups, and Tukey’s post-hoc test was employed for intra-group pairwise comparison