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Table 3 Echocardiographic results of mice after alteration of ADRB3 and overexpression of miR-18a

From: The crosstalk of HDAC3, microRNA-18a and ADRB3 in the progression of heart failure

Group\parameter

LVPWD (mm)

IVSD (mm)

LVEDD (mm)

LVESD (mm)

LVEF (%)

LVFS (%)

HF + sh-NC

1.26 ± 0.14

0.74 ± 0.08

4.57 ± 0.58

3.87 ± 0.49

15.33 ± 1.01

15.13 ± 1.23

HF + sh-ADRB3

1.75 ± 0.19*

0.51 ± 0.07*

3.70 ± 0.31*

2.83 ± 0.21 *

23.48 ± 2.01*

24.13 ± 2.54*

HF + miR-18a-agomir + oe-NC

1.84 ± 0.17

0.57 ± 0.06

3.54 ± 0.31

2.66 ± 0.24

24.83 ± 1.59

26.32 ± 2.28

HF + miR-18a-agomir + oe-ADRB3

1.31 ± 0.08#

0.82 ± 0.09 #

4.37 ± 0.50 #

3.67 ± 0.42 #

15.99 ± 2.34 #

16.21 ± 1.14 #

  1. * p < 0.05 vs. HF mice treated with sh-NC. # p < 0.05 vs. HF mice treated with miR-18a-agomir + oe-NC. One-way ANOVA was utilized for comparisons among multiple groups, and Tukey’s post-hoc test was employed for intra-group pairwise comparison
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Cell & Bioscience

ISSN: 2045-3701

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