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Table 2 Hemodynamic indicators of mice after miR-18a inhibition

From: The crosstalk of HDAC3, microRNA-18a and ADRB3 in the progression of heart failure

Group\parameter

LVSP(mm Hg)

LEVDP(mm Hg)

dp/dt(mm Hg/s)

-dp/dt(mm Hg/s)

Sham

112.27 ± 8.13

7.62 ± 0.38

8257.61 ± 976.83

9848.71 ± 856.87

HF

86.31 ± 5.61*

25.91 ± 1.91*

6336.27 ± 550.42*

5563.47 ± 623.61*

HF + NC-agomir

79.28 ± 6.34

24.66 ± 1.03

6762.82 ± 535.68

5442.23 ± 403.98

HF + miR-18a-agomir

97.86 ± 12.78#

8.46 ± 0.78#

8019.39 ± 814.23#

9659.33 ± 883.61#

  1. * p < 0.05 vs. sham-operated mice; # p < 0.05 vs. the HF mice injected with NC-agomir. One-way ANOVA was utilized for comparisons among multiple groups, and Tukey’s post-hoc test was employed for intra-group pairwise comparison
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Cell & Bioscience

ISSN: 2045-3701

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