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Table 2 Hemodynamic indicators of mice after miR-18a inhibition

From: The crosstalk of HDAC3, microRNA-18a and ADRB3 in the progression of heart failure

Group\parameter LVSP(mm Hg) LEVDP(mm Hg) dp/dt(mm Hg/s) -dp/dt(mm Hg/s)
Sham 112.27 ± 8.13 7.62 ± 0.38 8257.61 ± 976.83 9848.71 ± 856.87
HF 86.31 ± 5.61* 25.91 ± 1.91* 6336.27 ± 550.42* 5563.47 ± 623.61*
HF + NC-agomir 79.28 ± 6.34 24.66 ± 1.03 6762.82 ± 535.68 5442.23 ± 403.98
HF + miR-18a-agomir 97.86 ± 12.78# 8.46 ± 0.78# 8019.39 ± 814.23# 9659.33 ± 883.61#
  1. * p < 0.05 vs. sham-operated mice; # p < 0.05 vs. the HF mice injected with NC-agomir. One-way ANOVA was utilized for comparisons among multiple groups, and Tukey’s post-hoc test was employed for intra-group pairwise comparison