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Fig. 4 | Cell & Bioscience

Fig. 4

From: Structure, kinetic properties and biological function of mechanosensitive Piezo channels

Fig. 4

Adapted from Ge et al. [34]. b A lever-like mechano-gating model in Piezo1. The blue and red dashed arrows indicate input and output forces, respectively

Model of the lever-like mechanotransduction model. The curved blades can act as a mechanosensor, while the beam structure, with residues Ll1342 and Ll1345 acting as a pivot, can act as a lever-like apparatus. Coupling of the distal blades and central pore through the lever-like apparatus converts mechanical force into cation conduction. a Proposed model of the force-induced gating of Piezo channels. The blue and orange models represent the channel in its closed and open states, respectively. Red dashed lines indicate possible ion-conduction pathways.

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