Table 1 Gene Ontology Biological Process analysis of for Ccm3^ECKO mice RNA-Seq results

Hydrogen ion transmembrane transport

11

2.50E−13

NDUFA4, COX7A2, UQCRH, COX8A, COX7C, COX6B1, COX6A1, COX5A, UQCRQ, COX6C, UQCRB

Mitochondrial electron transport, cytochrome c to oxygen

8

3.14E−12

NDUFA4, COX8A, COX7C, COX6B1, COX6A1, COX5A, COX5B, COX6C

Mitochondrial ATP synthesis coupled proton transport

7

4.95E−10

ATP5E, ATP5J2, ATP5L, ATP5O, ATP5G2, ATP5G1, COX5B

ATP biosynthetic process

6

2.35E−07

ATP5E, ATP5J2, ATP5L, ATP5O, ATP5G2, ATP5G1

Mitochondrial electron transport, NADH to ubiquinone

6

3.50E−06

NDUFA4, NDUFB11, NDUFB5, NDUFA8, NDUFC2, NDUFA13

Generation of precursor metabolites and energy

5

1.17E−04

COX8A, COX7C, COX6A1, ATPIF1, COX6C

ATP synthesis coupled proton transport

4

1.50E−04

ATP5L, ATP5O, ATP5G2, ATP5G1

Mitochondrial respiratory chain complex I assembly

5

2.30E−04

NDUFB11, NDUFB5, NDUFA8, NDUFC2, NDUFA13

Cell–cell adhesion

8

3.07E−04

CCT8, WASF2, S100A11, RANBP1, EEF1D, PARK7, AHNAK, ANXA2

Mitochondrial electron transport, ubiquinol to cytochrome c

3

0.002261

UQCRH, UQCRQ, UQCRB

Angiogenesis

6

0.004235

PTPRB, CAV1, CLIC4, WASF2, ATPIF1, ANXA2