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Fig. 5 | Cell & Bioscience

Fig. 5

From: ATPIF1 maintains normal mitochondrial structure which is impaired by CCM3 deficiency in endothelial cells

Fig. 5

Overexpression ATPIF1 restore the signaling changes caused by CCM3-KO at early stage. a change of inflammatory pathway and mitophagy in CRISPR-CCM3 EPCS. b change of Tie2, p-Tie2 and KLF4 in selected CRISPR-CCM3 EPCs and s-oeATPIF1 EPCs. c MG132 (10 μM) treatment in CRISPR-CCM3, s-oeATPIF1 and CRISPR-CCM3 + s-oeATPIF1 EPCs. d ATPIF1 mRNA expression in s-oeATPIF1 and CRISPR-CCM3 + s-oeATPIF1 EPCs, *p < 0.05, **p < 0.01, ***p < 0.001. e different changes of Tie2 and KLF4 in CIRPSR-CCM3 + s-oeATPIF1 and s-oeATPIF1 + CRISPR-CCM3 EPCs. f the change of PINK1 after s-oeATPIF1 treatment. g overexpression CCM3 in CRISPR-CCM3 EPCs for 2 days or 5 days, vector was used as negative control

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Cell & Bioscience

ISSN: 2045-3701

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