Fig. 2

Targeting of CNS glucose metabolism in amyotrophic lateral sclerosis (ALS). Targeting CNS glucose metabolism has the potential to reduce the onset and progression of ALS. Possible approaches or targets in the glucose metabolism pathway include activation of glucose transport, glycolysis, pentose phosphate pathway (PPP), and pyruvate entry into the TCA cycle, facilitation of glycogen degradation, provision of alternative energy substrates, improving oxidative phosphorylation (OXPHOS) and ATP generation, using antioxidants targeting mitochondrial reactive oxygen species (ROS) as well as improving overall mitochondrial function and neuroglial interactions