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Fig. 3 | Cell & Bioscience

Fig. 3

From: Knockdown of Parkinson’s disease-related gene ATP13A2 reduces tumorigenesis via blocking autophagic flux in colon cancer

Fig. 3

ATP13A2 promotes stem-like traits of colon cancer cells in vitro. a Representative images (Left panel) and colony counts (Right panel) of two colon cancer cell lines (HCT-116, SW480) treated with siATP13A2 and siNC. b Representative images (Left panel) and colony counts (Right panel) in two colon cancer cell lines (HCT-116, SW480) transfected with the ATP13A2 overexpression vector (OEATP13A2) and the empty vector (mock). c Representative images (Left panel) and sphere counts (Right panel) of siATP13A2-SW480 and siNC-SW480, OEATP13A2-SW480 and mock-SW480 cell. Scale bar = 100 µm. d Western blotting for SOX2 and OCT4 in SW480 and HCT-116 cells with down- and upregulated-ATP13A2 respectively, compared with control cells. **, P < 0.01

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