Table 1 Functions of EZH2-PTMs

Phosphorylation

S21

AKT

Promote tumorigenesis

Breast cancer, prostate cancer, GBM

[31, 33, 42]

Y244

JAK3

Promote cells proliferation

NKTL

[45]

S363

GSK3β

Decrease cells proliferation

Breast cancer

[46]

T350 in human T345 in mouse

CDK1

Inhibit tumorigenesis

and metastasis

Breast cancer, lung cancer,

[37, 74]

T492 in human

T487 in mouse

CDK1

Inhibit tumorigenesis

and metastasis

Breast cancer, lung cancer,

[37, 74]

Y646 in human

Y641in mouse

JAK2

Inhibit tumorigenesis

Lymphoma

[48]

T261

CDK5

Inhibit metastasis

Pancreatic cancer

[50]

S220

MELK

Promote cells proliferation

NKTL

[51]

T367

p38

Promote metastasis

Breast cancer

[52]

T416

CDK2

Promote tumorigenesis

Breast cancer

[53, 54]

T311

AMPK

Inhibit tumorigenesis

Breast cancer, ovarian cancer

[55]

O-GlcNAcylation

S73, S84, S87, T313 and S729

OGT

Regulates the stability and enzymatic activity of EZH2

Breast cancer

[36, 59]

Acetylation

K348

PCAF

Promote cell migration and invasion

Lung cancer

[37]

Methylation

K307

SMYD2

Promote tumorigenesis and metastasis

Breast cancer

[39]

K735

SETD2

Inhibit metastasis

Prostate cancer

[73]

K342

PRMT1

Promote metastasis

Breast cancer

[74, 75]

Ubiquitination

–

Praja1

Inhibit metastasis

Breast cancer

[38]

K421

Smurf2

Inhibit metastasis

Prostate cancer

[85]

-

β-TrCP

Inhibit tumorigenesis

Lymphoma

[48]

–

TRAF6

Inhibit tumorigenesis and metastasis

Prostate cancer, breast cancer

[74, 84]

–

FBW7

Inhibit cell migration and invasion

Pancreatic cancer

[50]

–

CHIP

Inhibit tumorigenesis

Head and neck cancer

[83]

Deubiquitination

–

ZRANB1

Promote tumorigenesis and metastasis

Breast cancer

[99]

–

USP7

Promote tumorigenesis and metastasis

Colon cancer prostate cancer

[101, 102]

–

USP1

Promote tumorigenesis

Glioma

[103]

K222

USP36

Promote cells proliferation

NKTL

[51]