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Table 1 Functions of EZH2-PTMs

From: Post-translational modifications of EZH2 in cancer

Type of PTMs Site Catalyzing enzyme Biological functions Cancer connection Refs
Phosphorylation S21 AKT Promote tumorigenesis Breast cancer, prostate cancer, GBM [31, 33, 42]
Y244 JAK3 Promote cells proliferation NKTL [45]
S363 GSK3β Decrease cells proliferation Breast cancer [46]
T350 in human T345 in mouse CDK1 Inhibit tumorigenesis
and metastasis
Breast cancer, lung cancer, [37, 74]
T492 in human
T487 in mouse
CDK1 Inhibit tumorigenesis
and metastasis
Breast cancer, lung cancer, [37, 74]
Y646 in human
Y641in mouse
JAK2 Inhibit tumorigenesis Lymphoma [48]
T261 CDK5 Inhibit metastasis Pancreatic cancer [50]
S220 MELK Promote cells proliferation NKTL [51]
T367 p38 Promote metastasis Breast cancer [52]
T416 CDK2 Promote tumorigenesis Breast cancer [53, 54]
T311 AMPK Inhibit tumorigenesis Breast cancer, ovarian cancer [55]
O-GlcNAcylation S73, S84, S87, T313 and S729 OGT Regulates the stability and enzymatic activity of EZH2 Breast cancer [36, 59]
Acetylation K348 PCAF Promote cell migration and invasion Lung cancer [37]
Methylation K307 SMYD2 Promote tumorigenesis and metastasis Breast cancer [39]
K735 SETD2 Inhibit metastasis Prostate cancer [73]
K342 PRMT1 Promote metastasis Breast cancer [74, 75]
Ubiquitination Praja1 Inhibit metastasis Breast cancer [38]
K421 Smurf2 Inhibit metastasis Prostate cancer [85]
- β-TrCP Inhibit tumorigenesis Lymphoma [48]
TRAF6 Inhibit tumorigenesis and metastasis Prostate cancer, breast cancer [74, 84]
FBW7 Inhibit cell migration and invasion Pancreatic cancer [50]
CHIP Inhibit tumorigenesis Head and neck cancer [83]
Deubiquitination ZRANB1 Promote tumorigenesis and metastasis Breast cancer [99]
USP7 Promote tumorigenesis and metastasis Colon cancer prostate cancer [101, 102]
USP1 Promote tumorigenesis Glioma [103]
K222 USP36 Promote cells proliferation NKTL [51]