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Table 1 Roles of m6A regulators in breast cancer

From: Emerging roles of N6-methyladenosine (m6A) modification in breast cancer

m6A regulators Role in cancer Biological function Target/signaling axis Refs.
Writers
 METTL3 Oncogene Promote cell proliferation and growth HBXIP/let-7g/METTL3/HBXIP [60]
Promote proliferation and migration   [62]
Promote cell proliferation, tumor growth; Inhibit cell apoptosis Bcl-2 [61]
 METTL14 Oncogene Promote proliferation and migration   [62]
Promote cell migration and invasion Has-miR-146a-5p [76]
Promote cell proliferation and colony formation and inhibit cell apoptosis LNC942-METTL14-CXCR4/CYP1B1 [71]
Tumor suppressor Suppress cell viability, colony formation and migratory abilities   [64]
 KIAA1429 Oncogene Promote proliferation and migration CDK1 [65]
 Hakai Tumor suppressor Suppress cell proliferation and migration ERα [79]
Erasers
 FTO Oncogene Promote cell proliferation, colony formation and metastasis BNIP3 [67]
 ALKBH5 Oncogene Promote cell viability, colony formation and migratory abilities   [64]
Increase the percentage of breast cancer stem cells NANOG [82]
Promote metastasis from breast to lungs NANOG and KLF4 [83]
Tumor suppressor Suppress proliferation and migration   [76]
Readers
 YTHDF3 Oncogene Independent prognostic factor for overall survival   [25]
 hnRNPC Oncogene Promote cell proliferation and tumor growth dsRNA-induced interferon response [72]
hnRNPA2/B1 Oncogene Promote cell proliferation, decrease apoptosis, and prolong the S phase of the cell cycle STAT3 and ERK1/2 signaling pathway [73]
Tumor suppressor Suppress EMT and metastasis PFN2 [86]
 IGF2BP Oncogene Promote stemness of breast cancer cells Myc [84]
 eIF3m Oncogene Promote the cell proliferation, migration, invasion as well as suppress apoptosis in TNBC   [71]
 eIF3g Oncogene Promote lymph node metastasis hnRNPU, HSZFP36 and β-actin [87]