Table 1 Roles of m⁶A regulators in breast cancer

Writers

 METTL3

Oncogene

Promote cell proliferation and growth

HBXIP/let-7g/METTL3/HBXIP

[60]

Promote proliferation and migration

[62]

Promote cell proliferation, tumor growth; Inhibit cell apoptosis

Bcl-2

[61]

 METTL14

Oncogene

Promote proliferation and migration

[62]

Promote cell migration and invasion

Has-miR-146a-5p

[76]

Promote cell proliferation and colony formation and inhibit cell apoptosis

LNC942-METTL14-CXCR4/CYP1B1

[71]

Tumor suppressor

Suppress cell viability, colony formation and migratory abilities

[64]

 KIAA1429

Oncogene

Promote proliferation and migration

CDK1

[65]

 Hakai

Tumor suppressor

Suppress cell proliferation and migration

ERα

[79]

Erasers

 FTO

Oncogene

Promote cell proliferation, colony formation and metastasis

BNIP3

[67]

 ALKBH5

Oncogene

Promote cell viability, colony formation and migratory abilities

[64]

Increase the percentage of breast cancer stem cells

NANOG

[82]

Promote metastasis from breast to lungs

NANOG and KLF4

[83]

Tumor suppressor

Suppress proliferation and migration

[76]

Readers

 YTHDF3

Oncogene

Independent prognostic factor for overall survival

[25]

 hnRNPC

Oncogene

Promote cell proliferation and tumor growth

dsRNA-induced interferon response

[72]

hnRNPA2/B1

Oncogene

Promote cell proliferation, decrease apoptosis, and prolong the S phase of the cell cycle

STAT3 and ERK1/2 signaling pathway

[73]

Tumor suppressor

Suppress EMT and metastasis

PFN2

[86]

 IGF2BP

Oncogene

Promote stemness of breast cancer cells

Myc

[84]

 eIF3m

Oncogene

Promote the cell proliferation, migration, invasion as well as suppress apoptosis in TNBC

[71]

 eIF3g

Oncogene

Promote lymph node metastasis

hnRNPU, HSZFP36 and β-actin

[87]