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Fig. 1 | Cell & Bioscience

Fig. 1

From: Emerging roles of N6-methyladenosine (m6A) modification in breast cancer

Fig. 1

The molecular mechanism involved in m6A modification of consensus adenosine (A) bases. This is a dynamic and reversible epigenetic modification that is regulated by “writers” and “erasers.” m6A methylation is primarily catalyzed by the m6A methyltransferase complex comprising METTL3/METTL14/WTAP and other regulatory proteins (RBM15/15B, KIAA1429, Hakai, or ZC3H13). The erasers mainly include FTO, ALKBH5, ALKBH3, and ALKBH1. In addition to writers and erasers, “readers” are binding proteins that recognize m6A marks in the RNA. m6A modification can affect multiple steps in RNA processing, such as RNA splicing, export, translation, stabilization, and decay

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