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Fig. 6 | Cell & Bioscience

Fig. 6

From: Iron accumulation in macrophages promotes the formation of foam cells and development of atherosclerosis

Fig. 6

Iron chelation therapy prevents severe atherosclerosis in Apoe−/− Fpn1LysM/LysM mice. Eight-week-old male Apoe−/−Fpn1LysM/LysM mice were fed a High fat diet and randomly divided into 2 groups: the vehicle—(saline) and iron chelator-treated (DFP, 80 mg/kg) groups. a Representative images of Oil Red O staining of aortas. b Quantification of the aortic lesion area, n = 10. c, d Determination of aortic root lesion area and size, n = 4. e, f Representative images and quantification of Oil Red O staining of the aortic roots of Apoe−/−Fpn1LysM/LysM mice, n = 4. g Representative images of IHC staining for ABCA1 and ABCG1 and the quantification of the stained areas, n = 4. Scale bar, 100 μm. Data are presented as the mean ± SEM. Statistical significance was determined using Student’s t-test and one-way ANOVA followed by Tukey’s multiple comparisons test. *P < 0.05 Apoe−/−Fpn1LysM/LysM + saline vs. Apoe−/− mice, P < 0.05, †††P < 0.001 Apoe−/−Fpn1LysM/LysM + DFP vs. Apoe−/−Fpn1LysM/LysM + saline

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