Fig. 3

Macrophage-specific Fpn1 deficiency increases arterial and systemic inflammation. a, b Western blot analysis of IL-1β, IL-6 and TNF-α in the aortas of Apoe^−/− and Apoe^−/−Fpn1^LysM/LysM mice, n = 4. Determination of the concentrations of serum hepcidin (c), IL-6 (d), IL-1β (e), TNF-α (f), MCP-1 (g), and ICAM-1 (h) in Apoe^−/− and Apoe^−/−Fpn1^LysM/LysM mice, n = 5. Data are presented as the mean ± SEM. Statistical significance was determined using Student’s t-test. *P < 0.05, **P < 0.01, and ***P < 0.001 vs. Apoe^−/− mice. NS, no significance