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Fig. 2 | Cell & Bioscience

Fig. 2

From: Iron accumulation in macrophages promotes the formation of foam cells and development of atherosclerosis

Fig. 2

Macrophage-specific Fpn1 deficiency increases oxidative stress in the aorta. a Representative images of DHE staining in the aortas of Apoe−/− and Apoe−/−Fpn1LysM/LysM mice and b quantification of DHE fluorescence intensity. c Malondialdehyde (MDA) content in the aortas of Apoe−/− and Apoe−/−Fpn1LysM/LysM mice. d Representative images of IHC staining for 8-OHdG and quantification of stained areas. e Western blot analysis of catalase (CAT), heme oxygenase 1 (HO-1) and superoxide dismutase (SOD2) protein expression in the aortas of Apoe−/− and Apoe−/−Fpn1LysM/LysM mice and f the quantification of this analysis. Data are presented as the mean ± SEM; n = 4. Statistical significance was determined using Student’s t-test. *P < 0.05, **P < 0.01, and ***P < 0.001 vs. Apoe−/− mice

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