Fig. 6

Role of BTB and non-BTB domains of KLHL18 in non-small cell lung cancer cells. a MTS assay based on KLHL18-ΔBTB- and KLHL18-ΔKelch-transfected NSCLC cell lines; left and right panels show NCI-A549 and NCI-H1299 cell lines, respectively, *P < 0.05, **P < 0.01. b The effect of KLHL18 and its splice variants on the colony-forming ability of NSCLC cell lines. The right panel shows the quantification of colonies,*P < 0.05, **P < 0.01. c The effect of KLHL18 and its splice variants on the invasive ability of NSCLC cells. The graph on the right side indicates the number of cells passing through the Matrigel, *P < 0.05, **P < 0.01. d The effect of KLHL18 and its splice variants on the migration of NSCLC cells. The graph on the right side indicates the cell migration distances *P < 0.05, **P < 0.01