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Fig. 5 | Cell & Bioscience

Fig. 5

From: KLHL18 inhibits the proliferation, migration, and invasion of non-small cell lung cancer by inhibiting PI3K/PD-L1 axis activity

Fig. 5

KLHL18 acts as an adaptor protein to interact with CUL3 and PI3Kp85α through different domains. a Locations of the deletions of KLHL18 domains. b Expression efficiency of KLHL18 splice variants in HEK-293 T cells. c Co-IP using the spliced variants of KLHL18 indicated that CUL3 bound to the BTB domain, whereas PI3Kp85α bound to the non-BTB domain. d The potential mechanism through which KLHL18 exerts its effects in NSCLC cell lines

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Cell & Bioscience

ISSN: 2045-3701

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