Fig. 1

Low KLHL18 expression in human non-small cell lung cancer (NSCLC) is associated with poor prognosis. a KLHL18 expression in lung adenocarcinoma (LUAD) is lower than in normal lung tissue. P < 0.05. KLHL18 expression in lung squamous cell carcinoma (LUSC) is lower than in normal lung tissue. P < 0.05. b The expression of KLHL18 protein in immunohistochemical sections of [a] normal bronchial epithelial tissue, [b] normal alveolar tissue, [c] highly differentiated squamous cell carcinoma, [d] highly differentiated LUAD, [e] poorly differentiated squamous cell carcinoma, and [f] poorly differentiated LUAD. c qRT-PCR analysis of the expression level of KLHL18 in 22 pairs of NSCLC and adjacent tissues, ***P < 0.0001. d Prognostic analysis of immunohistochemistry results in 37 clinical samples shows that patients with high KLHL18 protein expression had longer survival times and better prognosis. P < 0.05. e Kaplan–Meier curves showing that low-level KLHL18 protein expression was associated with poor prognosis of NSCLC, P = 0.0045. f Cox regression analysis shows that KLHL18 is an independent risk factor affecting NSCLC patients’ prognosis, P < 0.0001. g Low expression of KLHL18 protein was also associated with poor prognosis in patients with breast cancer, renal papillary cell carcinoma, head, and neck squamous cell carcinoma, and rectal adenocarcinoma, P < 0.05