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Fig. 5 | Cell & Bioscience

Fig. 5

From: Secretory phospholipase A2-X (Pla2g10) is a novel progesterone receptor target gene exclusively induced in uterine luminal epithelium for uterine receptivity in mice

Fig. 5

In vivo delivery of siRNAs for Pla2g10 interferes with embryo implantation. a Immunofluorescence analysis represent PLA2G10 in mouse uteri treated with siNC or siPla2g10 (100 pmol per uterine horn). Green and red colors indicate the presence of PLA2G10 and nuclei, respectively. LE luminal epithelium, S stroma. Scale bar: 20 µm. b Representative photograph of a mouse uterus injected with siNC or siPla2g10 with arrowheads indicating implantation sites. c Number of implantation site (IS) was counted on day 6 of pregnancy in mouse uteri treated with siNC or siPla2g10 (100 pmol per uterine horn, n = 8 per each group). d Photomicrographs of representative uterine sections showing H&E staining and ALP activity on day 6 IS in the uterus with siNC or siPla2g10. Right panels of H&E show the enlarged images of IS. Scale bar: 100 µm. e Immunofluorescence staining of ARG2 on day 6 IS in the uterus with siNC or siPla2g10. Arrowheads indicate the location of implanted embryo. Scale bar: 100 µm. *p < 0.05

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