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Table 1 Animal studies that investigated the therapeutic effects of resveratrol on depression

From: Molecular and biological functions of resveratrol in psychiatric disorders: a review of recent evidence

Disease

Dose of resveratrol

Model

Findings

Publish year

Refs.

Chronic unpredictable mild stress-induced depression

80 mg/kg

In vivo

Inhibited neuro-inflammation, oxidative stress, and apoptosis, increased hippocampal BDNF and β-catenin levels

2018

[84]

Ovariectomy-induced depression

20 mg/kg

In vivo

Decreased activation of microglia, NF-kB, and NLRP3 in hippocampus, increased levels of Sirt1

2019

[85]

Chronic unpredictable mild stress-induced depression

80 mg/kg

In vivo

Inhibited oxidative stress, apoptosis and inflammation elevation of serum levels of testosterone and β-catenin

2019

[86]

Chronic restraint stress- induced depression

80 mg/kg

In vivo

Increased BDNF levels, and Bcl-2 expression in hippocampus, decreased Bax mRNA expression

2016

[7]

Subclinical hypothyroidism

15 mg/kg

In vivo

Decreased TSH, TRH, corticoesterone, and CRH hormones, increased GSK3β phosphorylation, cyclin D1 and c-myc, decreased β-catenin phosphorylation, decreased activity of HPA axis

2016

[99]

Chronic unpredictable mild stress-induced depression

15 mg/kg/day

In vivo

Decreased corticosterone and CRH, increased IL-6, CRP, TNF-α, BDNF, βcatenin phosphorylation, decreased the phosphorylation of GSK-3β in hippocampus

2017

[100]

Chronic unpredictable mild stress-induced depression

40 or 80 mg/kg/day

In vivo

activated Akt/GSK3β pathway and regulated pro-inflammatory cytokines and apoptosis

2019

[101]

Ouabain-induced depression

10 mg/kg

In vitro/in vivo

Decreased oxidative stress and neuro-inflammation

2018

[102]

Chronic unpredictable mild stress-induced depression

50 mg/kg

In vivo

Increased hippocampal ATP levels, mitochondrial DNA, the expressions of SIRT1 and PGC1α, decreased Na+-K+-ATPase and pyruvate levels, increased serotonin levels, decreased SERT in the hippocampus

2020

[87]

LPS-induced depression

0.3 mg/kg

In vivo

Improved apoptosis and oxidative stress in hippocampus and depressant-like behaviors

2017

[88]

LPS-induced depression

20 mg/kg

In vivo

Enhanced neurogenesis, upregulated Sirt1, and inhibited NF-kB activation

2016

[89]

Chronic unpredictable mild stress-induced depression

10, 20 and 30 mg/kg

In vivo

Increased dopamine and serotonin in the prefrontal cortex and increased NPY expression in the brain

2019

[90]