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Table 3 Multivariable analysis on the prognosis role of CTNNB1 and POLE mutations and CIN signatures in EBRT subgroup

From: Integrating pathology, chromosomal instability and mutations for risk stratification in early-stage endometrioid endometrial carcinoma

EBRT Disease-free survival Overall survival
n HR (95% CI) P n HR (95% CI) P
CIN25
 Low 30 1   11 1  
 High 49 2.772 (0.735–10.459) 0.132 68 0.977
CTNNB1
 Wild type 73 1   73 1  
 Mutation 6 4.907 (1.008–23.880) 0.049 6 6.654 (1.280–34.586) 0.024
POLE
 Wild type 72t 1   72 1  
 Mutation 7 0.740 (0.093–5.872) 0.776 7 0.983
CIN70
 Low 33 1   12 1  
 High 46 3.039 (0.812–11.369) 0.092 67 0.976
CTNNB1
 Wild type 73 1   73 1  
 Mutation 6 4.889 (1.013–23.602) 0.048 6 6.494 (1.249–33.759) 0.026
POLE
 Wild type 72 1   72 1  
 Mutation 7 0.727 (0.092-5.755) 0.763 7 0.983