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Table 2 Multivariable analysis on the prognosis role of CIN signatures and CTNNB1 mutation in OB and VBT subgroups without POLE mutation

From: Integrating pathology, chromosomal instability and mutations for risk stratification in early-stage endometrioid endometrial carcinoma

OB Disease-free survival Overall survival
n HR (95% CI) P n HR (95% CI) P
CIN25
 Low 61 1   33 1  
 High 50 2.295 (0.749–7.029) 0.146 78 0.97
CTNNB1
 Wild type 67 1   67 1  
 Mutation 44 1.400 (0.473–4.138) 0.543 44 12.393 (1.325–99.433) 0.022
CIN70
 Low 24 1   44 1  
 High 87 0.958 67 0.966
CTNNB1
 Wild type 67 1   67 1  
 Mutation 44 1.576 (0.545–4.554) 0.401 44 12.289 (1.431–105.564) 0.022
VBT n HR (95% CI) P n HR (95% CI) P
CIN25
 Low 62 1   63 1  
 High 20 6.183 (1.416–26.991) 0.015 19 2.644 (0.372–18.807) 0.331
CTNNB1
 Wild type 60 1   60 1  
 Mutation 22 0.562 (0.065–4.838) 0.6 22 0.978
CIN70
 Low 50 1   55 1  
 High 32 6.032 (1.215–29.949) 0.028 27 2.311 (0.325–16.422) 0.403
CTNNB1
 Wild type 60 1   60 1  
 Mutation 22 0.307 (0.038–2.500) 0.27 22 0.976