Table 2 Multivariable analysis on the prognosis role of CIN signatures and CTNNB1 mutation in OB and VBT subgroups without POLE mutation
OB | Disease-free survival | Overall survival | ||||
|---|---|---|---|---|---|---|
n | HR (95% CI) | P | n | HR (95% CI) | P | |
CIN25 | ||||||
 Low | 61 | 1 |  | 33 | 1 |  |
 High | 50 | 2.295 (0.749–7.029) | 0.146 | 78 | – | 0.97 |
CTNNB1 | ||||||
 Wild type | 67 | 1 |  | 67 | 1 |  |
 Mutation | 44 | 1.400 (0.473–4.138) | 0.543 | 44 | 12.393 (1.325–99.433) | 0.022 |
CIN70 | ||||||
 Low | 24 | 1 |  | 44 | 1 |  |
 High | 87 | – | 0.958 | 67 | – | 0.966 |
CTNNB1 | ||||||
 Wild type | 67 | 1 |  | 67 | 1 |  |
 Mutation | 44 | 1.576 (0.545–4.554) | 0.401 | 44 | 12.289 (1.431–105.564) | 0.022 |
VBT | n | HR (95% CI) | P | n | HR (95% CI) | P |
|---|---|---|---|---|---|---|
CIN25 | ||||||
 Low | 62 | 1 |  | 63 | 1 |  |
 High | 20 | 6.183 (1.416–26.991) | 0.015 | 19 | 2.644 (0.372–18.807) | 0.331 |
CTNNB1 | ||||||
 Wild type | 60 | 1 |  | 60 | 1 |  |
 Mutation | 22 | 0.562 (0.065–4.838) | 0.6 | 22 | – | 0.978 |
CIN70 | ||||||
 Low | 50 | 1 |  | 55 | 1 |  |
 High | 32 | 6.032 (1.215–29.949) | 0.028 | 27 | 2.311 (0.325–16.422) | 0.403 |
CTNNB1 | ||||||
 Wild type | 60 | 1 |  | 60 | 1 |  |
 Mutation | 22 | 0.307 (0.038–2.500) | 0.27 | 22 | – | 0.976 |