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Fig. 3 | Cell & Bioscience

Fig. 3

From: Integrating pathology, chromosomal instability and mutations for risk stratification in early-stage endometrioid endometrial carcinoma

Fig. 3

Prognostic significance of CIN signatures in different adjuvant radiotherapy subgroups. a AUCs for 5-year DFS based on CIN signatures, FGA and Aneuploidy Score in the OB subgroup excluding mutations of POLE and CTNNB1, in the VBT subgroup excluding POLE-mutant patients and in the EBRT and EBRT EEC subgroups without CTNNB1 mutations. b Kaplan–Meier plot for 5-year DFS based on CIN70 in the OB subgroup excluding mutations of POLE and CTNNB1. c Kaplan–Meier plot for 5-year DFS based on CIN25 in the VBT subgroup excluding POLE-mutant patients. d Kaplan–Meier plot for 5-year DFS based on CIN25 in CTNNB1 wild-type patients from the EBRT subgroup. e Kaplan–Meier plot for 5-year DFS based on CIN25 in CTNNB1 wild-type patients from EBRT EEC patients. P values in (b–(e) are calculations of the log-rank test. f Characteristics of recurrent patients in (b–(e). The cumulative bar chart represents the proportions of TCGA molecular subtypes, the proportions of CIN subgroups and the proportions of histopathological types. g AUCs for 5-year DFS and 10-year OS based on CIN signatures, FGA and Aneuploidy Score in CTNNB1-mutant patients from the OB subgroup. h Kaplan–Meier plots for 5-year DFS and 10-year overall survival (OS) based on CIN70 in CTNNB1-mutant patients from the OB subgroup. P values are calculations of the log-rank test

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