Fig. 2

Relationships between CIN and molecular prognostic factors. a AUCs for 5-year DFS based on CIN25 and CIN70 in the OB, VBT, EBRT and EBRT EEC subgroups. b Kaplan–Meier plot for 5-year DFS based on TCGA molecular subtypes. c Boxplot of CIN25 and CIN70 expression in patients belonging to the four TCGA molecular subtypes. The Levene test for homogeneity demonstrated unequal variances among these four groups. P values are calculations of Welch-corrected ANOVA with Games-Howell post hoc tests. d Boxplot of CIN25 and CIN70 expression in POLE or CTNNB1 wild-type versus mutant patients from the OB, VBT and EBRT subgroups. P values are Mann–Whitney test calculations. e Kaplan–Meier plots for 5-year DFS and 10-year OS based on POLE mutation status in the OB and VBT subgroups. f Kaplan–Meier plots for 5-year DFS and 10-year OS based on CTNNB1 mutation status in the OB and EBRT subgroups. P values in (b), (e) and (f) are calculations of the log-rank test. P values: *p < 0.05, **p < 0.01, ***p < 0.001, n.s. not significantly different