Fig. 1

MAPK4 deficiency ameliorates the pathologic injury of ALI. a Schematic diagram showing WT C57BL/6 mice or MAPK4^−/− mice were treated with i.p. 10 mg/kg or 15 mg/kg LPS, respectively. b WT C57BL/6 mice (n = 12) and MAPK4^−/− mice (n = 12) were administered with i.p. 15 mg/kg LPS, respectively. The survival time of mice were obtained. WT C57BL/6 mice (n = 5–6) and MAPK4^−/− mice (n = 5–6) were administered with i.p. 10 mg/kg LPS, respectively. 24 h later, c The weight index, d lung weight index (lung weight/weight) and e lung wet-dry ratio were obtained, respectively. f The protein concentration in BALF was detected. g The pathology of lung tissues was analyzed by HE staining. Arrows indicate infiltrated cells. Scale bar = 50 μm. h Lung injury score was obtained. Data were presented as the mean ± SEM. *p < 0.05, **p < 0.01