Table1 Advantages and disadvantages among different cell types for the treatment of liver diseases
From: Mesenchymal stem cell therapy for liver disease: full of chances and challenges
Cell types | Advantages | Disadvantages | References |
|---|---|---|---|
Hepatocytes | Suitable for many enzyme deficiency states, metabolic diseases, coagulation disorders, as well as liver failure Key metabolic and synthetic cell | Donor organ shortages Limitations in transplanted cell engraftment and proliferation Susceptible to infection with hepatitis viruses | [104] |
Hemopoietic cells | Plasticity is not limited to the tissue they derived from | Procedure for obtaining (bone marrow aspirate) | |
Immune cells | Easy to isolate and expand Autologous therapy | Only used in HCC Tend to form inflammatory storms | [107] |
EPCs | Appear anti-fibrotic and pro-regenerative Autologous therapy | Isolation process is complicated Clinical use unclear | |
MSCs | Easy to isolate and expand Multiple differentiation Generally immune tolerance Could be used with other cell types to reduce inflammation Secretome can be used Both autologous and allogeneic therapy | Some clinical studies have been negative Poorly defined cell type |