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Table1 Advantages and disadvantages among different cell types for the treatment of liver diseases

From: Mesenchymal stem cell therapy for liver disease: full of chances and challenges

Cell types Advantages Disadvantages References
Hepatocytes Suitable for many enzyme deficiency states, metabolic diseases, coagulation disorders, as well as liver failure
Key metabolic and synthetic cell
Donor organ shortages
Limitations in transplanted cell engraftment and proliferation
Susceptible to infection with hepatitis viruses
[104]
Hemopoietic cells Plasticity is not limited to the tissue they derived from Procedure for obtaining (bone marrow aspirate) [105, 106]
Immune cells Easy to isolate and expand
Autologous therapy
Only used in HCC
Tend to form inflammatory storms
[107]
EPCs Appear anti-fibrotic and pro-regenerative
Autologous therapy
Isolation process is complicated
Clinical use unclear
[108, 109]
MSCs Easy to isolate and expand
Multiple differentiation
Generally immune tolerance
Could be used with other cell types to reduce inflammation
Secretome can be used
Both autologous and allogeneic therapy
Some clinical studies have been negative
Poorly defined cell type
[5, 110,111,112]