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Fig. 3 | Cell & Bioscience

Fig. 3

From: Tunicamycin promotes metastasis through upregulating endoplasmic reticulum stress induced GRP78 expression in thyroid carcinoma

Fig. 3

Suppression of GRP78 expression partially decreases the ER stress agonist-induced metastasis in thyroid cancer cells. a Western blotting analysis of XBP1s, PERK and GRP78 protein expression in ARO and FRO cells when treated with TM (0–1 Î¼g/L). b Transwell assays were performed to assess the migration of ARO and FRO cells when treated with TM(1 μg/L). Bar graphs represent the average migration rate of ARO and AFO cells, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001. c Transwell assays were performed to assess the migration of siGRP78-transfected ARO and FRO cells when treated with TM(1 μg/L). Bar graphs represent the average migration rate of ARO and AFO cells, ∗p < 0.05, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001

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Cell & Bioscience

ISSN: 2045-3701

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