Table 4 Clinical trials conducted using adipose-derived mesenchymal stem cells for the treatment of SCI
From: Treatment of spinal cord injury with mesenchymal stem cells
References | Acute, subactute or chronic | AIS grade | Number of patients | Sources of MSCs | Route of administration | Number of cells | Frequency of injection | Safety outcome | Efficacy outcome |
|---|---|---|---|---|---|---|---|---|---|
[64] | Chronic | A, B and D | 14 | AT | Intrathecal | 9 × 107 ADSCs | 3 (monthly) | No AE | 10 patients have improved ASIA sensory score, 5 patients have improved ASIA motor score and 2 patients have improved voluntary anal contraction |
[65] | Chronic | A | 1 | AT | Intrathecal | 1 × 108 ADSCs | 1 | No AE | The patient showed improvement in ASIA motor and sensory score as well as better quality of life as indicated by the higher Global Health Score. |