Fig. 4
From: Rap1b but not Rap1a in the forebrain is required for learned fear
Rap1b is required for retrieval-induced c-Fos expression in PL. a Representative images showing c-Fos expression in PL of Rap1af/f and Rap1a cKO mice. Slices were stained with anti-c-Fos (red) antibody, nuclei were showed by DAPI (blue). Scale bar, 30 μm. b Quantitative analysis of data in a. c-Fos expressions were normalized to Rap1af/f CS only group. For CS only group: n = 12 slices from 4 mice per group. For learning group: n = 12 slices from 4 mice per group. c Representative images showing c-Fos expression in IL of Rap1af/f and Rap1a cKO mice. Scale bar, 30 μm. d Quantitative analysis of data in c. c-Fos expressions were normalized to Rap1af/f CS only group. For CS only group: n = 12 slices from 4 mice per group. For learning group: n = 12 slices from 4 mice per group. e Representative images showing c-Fos expression in PL of Rap1bf/f and Rap1b cKO mice. Scale bar, 30 μm. f Quantitative analysis of data in e. c-Fos expressions were normalized to Rap1bf/f CS only group. For CS only group: n = 12 slices from 4 mice per group. For learning group: n = 13 slices from 4 mice per group. g Representative images showing c-Fos expression in IL of Rap1bf/f and Rap1b cKO mice. Scale bar, 30 μm. h Quantitative analysis of data in g. c-Fos expressions were normalized to Rap1bf/f CS only group. For CS only group: n = 12 slices from 4 mice per group. For learning group: n = 13 slices from 4 mice per group. Data are presented as mean ± SEM; *p < 0.05, **p < 0.01