Skip to main content
Fig. 2 | Cell & Bioscience

Fig. 2

From: Conditional ablation of MAPK7 expression in chondrocytes impairs endochondral bone formation in limbs and adaptation of chondrocytes to hypoxia

Fig. 2

Mice with MAPK7 deficiency in chondrocytes displayed decreased cortical thickness and bone mass loss. a HE staining of distal femur sections from P60 mice. Boxed areas are magnified in the images at the bottom. Scale bar, 200 μm. b Three-dimensional reconstruction μCT images (n = 5) of (upper images) femur trabecular and (lower images) cortical bone in CON and Mapk7 CKO mice at P60. c–i Quantitative μCT analysis of CON and Mapk7 CKO femurs, including (c) cortical thickness, (d) bone mineral density (BMD), (e) bone volume/tissue volume ratio (BV/TV), (f) trabecular thickness, (g) trabecular number, (h) trabecular separation, and (i) the trabecular pattern factor. *P < 0.05 (Student’s t test). Data are presented as mean ± SD. j–l Immunofluorescence staining of (j) OSX, (k) OPN and (l) OCN on representative sections of proximal tibial growth plates from P7 mice

Back to article page

Cell & Bioscience

ISSN: 2045-3701

Contact us