Fig. 5

Role of MAPK/pERK signaling in Dzx-induced changes in STIM1 localization and upregulation of Orai1. a Upper panels, confocal microscopy images of cardiomyocytes under the indicated experimental conditions. Images show localization of STIM1 (red) with DAPI-labeled nuclei (blue). Lower panels, magnified views of the corresponding yellow boxed areas. b Representative confocal images of cardiomyocytes under the same conditions as in a. Images show localization of Orai1 (green) with DAPI-labeled nuclei (blue). c The graph shows mean Orail particle counts (± SEM, n = 5–6) from confocal images as in b. *p < 0.05