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Fig. 7 | Cell & Bioscience

Fig. 7

From: Disruption of zinc transporter ZnT3 transcriptional activity and synaptic vesicular zinc in the brain of Huntington’s disease transgenic mouse

Fig. 7

The mechanism of ZnT3 down-regulation and its effect on vesicular zinc in HD. a Transcription factor Sp1 binds to ZnT3 promoter and up-regulates its expression. Vesicular zinc is dependent on ZnT3 on the membrane of synaptic vesicles in the axonal terminal. b mHtt inhibits the binding of Sp1 to ZnT3 promoter. Down-regulated ZnT3 expression reduces the transport of zinc into synaptic vesicles. Zinc dyshomestasis contributes to synaptic dysfunction

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Cell & Bioscience

ISSN: 2045-3701

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