Fig. 4

Mutant huntingtin impairs ZnT3 protein and mRNA expression. a, b The expression of ZnT3 is decreased in cortex, striatum and hippocampus of TG mice aged from 14 to 20 weeks, compared to age-matched WT mice (a Western blot analysis, b RT-PCR analysis). Hip hippocampus. n = 4. *p < 0.05 compared to WT mice. c, d The expression of ZnT3 is decreased in 160Q BHK cells at different times after transfection, compared to 20Q BHK cells (c Western blot analysis, d RT-PCR analysis). n = 4. *p < 0.05 compared to 20Q BHK cells