Fig. 7

Schematic regulation of PDP1 in PDAC. Overexpression of PDP1 may activate PDH, which in turn accelerates the TCA cycle, which provides reducing equivalents in the form of NADH, FADH2, etc. for the ATP production by oxidative phosphorylation. The abundance of cellular ATP inhibits AMPK activation, restoring the mTOR signaling that can promote proliferation and invasion of PDAC cells