Table 1 Epigenetic regulation on different MMP genes

Histone modification

Histone methylation

MMP-1, MMP-3, MMP-9, MMP-13

Rheumatoid arthritis

[28]

MMP-9,

Diabetes

[29]

Histone acetylation

MMP-1 and MMP-3

Pulmonary tuberculosis

[17]

MMP-1 and MMP-13

Arthritis

[42]

MMP-9

Experimental autoimmune neuritis.

[38]

Histone phosphorylation

MMP‐2 and the MT1‐MMP/TIMP‐2 complex

Treponema denticola

[45]

DNA methylation

MMP-9

Diabetes

[49, 50]

MMP-2 and MMP-9

Periodontitis

[53]

MMP-3, MMP-9, MMP-13 , MMP-14

Osteoarthritis

[56]

MMP-14

Rheumatoid arthritis

[61]

Non-coding RNA

MicroRNAS

MMP-1 and MMP-3

Rheumatoid arthritis

[68, 70, 71]

MMP-12

Asthma

[81]

MMP-13

Osteoarthritis

[72]

MMP-14

Atherosclerotic plaque

[80]

Long non-coding RNA

MMP-2, MMP-3, MMP-9, and MMP-13

Osteoarthritis

[83]

MMP-1, MMP-3 and MMP-9

Temporomandibular joint osteoarthritis

[84]