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Table 1 Epigenetic regulation on different MMP genes

From: Epigenetic regulation of matrix metalloproteinases in inflammatory diseases: a narrative review

Epigenetic regulation MMPs Inflammatory diseases References
Histone modification Histone methylation MMP-1, MMP-3, MMP-9, MMP-13 Rheumatoid arthritis [28]
MMP-9, Diabetes [29]
Histone acetylation MMP-1 and MMP-3 Pulmonary tuberculosis [17]
MMP-1 and MMP-13 Arthritis [42]
MMP-9 Experimental autoimmune neuritis. [38]
Histone phosphorylation MMP‐2 and the MT1‐MMP/TIMP‐2 complex Treponema denticola [45]
DNA methylation   MMP-9 Diabetes [49, 50]
MMP-2 and MMP-9 Periodontitis [53]
MMP-3, MMP-9, MMP-13 , MMP-14 Osteoarthritis [56]
MMP-14 Rheumatoid arthritis [61]
Non-coding RNA MicroRNAS MMP-1 and MMP-3 Rheumatoid arthritis [68, 70, 71]
MMP-12 Asthma [81]
MMP-13 Osteoarthritis [72]
MMP-14 Atherosclerotic plaque [80]
Long non-coding RNA MMP-2, MMP-3, MMP-9, and MMP-13 Osteoarthritis [83]
MMP-1, MMP-3 and MMP-9 Temporomandibular joint osteoarthritis [84]
  1. MMP, matrix metalloproteinase