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Table 2 The body weight gain, splenic weight, and the concentrations of total arsenic (T-As, ng As/g tissue) in spleen of control and different experimental mice

From: Chronic arsenic exposure induces the time-dependent modulation of inflammation and immunosuppression in spleen

Experimental groups Duration (month) Dose (mg/L) Body weight gain (g) Splenic weight (g) T-As in spleen (ng/g)
Group 1 1 0 11.64 ± 1.83 0.11 ± 0.03 < LD
Group 2 1 25 11.98 ± 1.74 0.10 ± 0.03 31.46 ± 9.18
Group 3 1 50 11.76 ± 2.30 0.10 ± 0.02 39.95 ± 3.86
Group 4 3 0 19.61 ± 1.95 0.10 ± 0.03 < LD
Group 5 3 25 18.57 ± 3.86 0.10 ± 0.02 38.31 ± 5.87
Group 6 3 50 18.41 ± 1.27 0.10 ± 0.02 36.34 ± 19.82
Group 7 12 0 24.51 ± 3.59 0.10 ± 0.02 < LD
Group 8 12 25 23.21 ± 4.78 0.11 ± 0.02 47.80 ± 15.90
Group 9 12 50 24.80 ± 2.11 0.10 ± 0.03 52.42 ± 3.29
  1. Mice were treated with 25 mg/L and 50 mg/L NaAsO2 for 1, 3 and 12 months through drinking water ad libitum, and the body weight of the mice was recorded every week. At the treatment endpoints, the entire spleen was removed and weighed (mean ± SD, n = 10). The total arsenic (T-As) levels of spleen were determined by the HPLC-HG-AFS method. Results were expressed as mean ± SD (n = 3). The limit of detection (LD) for T-As was 1 μg/L
  2. * p < 0.05 compared with corresponding control mice