Table 1 Proteins that physically interact with canonical or prefoldin-like subunits, and research advances in different organisms and diseases

β

 PFDN1

Oncogene

Human

Cyclin A [36]

RABV [39]

Gastric cancer [35]

Lung cancer [36]

Colon cancer [37]

Nasopharyngeal carcinoma [38]

Mouse

Lymphocyte development [27]

Cytoskeletal defect [27]

 PFDN2

Oncogene

Human

γ-Synuclein [42]

Gastric cancer [35]

Breast cancer [40]

Metastatic urothelial carcinoma [41]

Plant [65]

 PFDN4

Oncogene

Human

Atherosclerosis [19]

Gastric cancer [35, 52]

Breast cancer [48, 49]

Colon cancer [51]

Hepatocellular carcinoma [50]

Atopic dermatitis [53]

 PFDN6

Human

Gastric cancer [35]

Acute lymphocytic leukemia [64]

Arabidopsis thaliana [76]

DELLA [67]

Caenorhabditis elegans

FOXO [77]

α

 PFDN3/VBP1

Anti-oncogene

Human

VHL [43]

pVHL [44]

hMSH4 [45]

HDAC1 [46]

Gastric cancer [35]

Arabidopsis thaliana

DELLA [67]

Caenorhabditis elegans [66]

 PFDN5/MM1

Anti-oncogene

Human

c-Myc [99]

TIF1β [101]

Rabring7 [127]

Egr-1 [128]

ARFP/F [129]

p73α [133]

p63α [134]

ΔNp63α [135]

Gastric cancer [35]

Secondary hyperparathyroidism [54, 55]

Colon cancer [60]

Mouse

Breast cancer [70– 73]

Arabidopsis thaliana

DELLA [67]

α-like

 URI/Bud27

Human

Cervical cancer [89]

Colon cancer [90]

Gastric cancer [91]

Mouse

c-Myc [88]

Hepatocellular carcinoma [85]

Yeast

Rpb5 [83]

TOR [93]

PFDN6 [94]

 UXT/Art-27

NF-κB [95]

Als2 [97]

Androgen receptor [96]

Centrosome component [98]

γ

 γ-prefoldin

Nanobiotechnology [32,33,34]