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Table 1 Proteins that physically interact with canonical or prefoldin-like subunits, and research advances in different organisms and diseases

From: The functions and mechanisms of prefoldin complex and prefoldin-subunits

Prefoldin subunits Function Organism Interactor Disease
β
 PFDN1 Oncogene Human Cyclin A [36]
RABV [39]
Gastric cancer [35]
Lung cancer [36]
Colon cancer [37]
Nasopharyngeal carcinoma [38]
Mouse   Lymphocyte development [27]
Cytoskeletal defect [27]
 PFDN2 Oncogene Human γ-Synuclein [42] Gastric cancer [35]
Breast cancer [40]
Metastatic urothelial carcinoma [41]
Plant [65]   
 PFDN4 Oncogene Human   Atherosclerosis [19]
Gastric cancer [35, 52]
Breast cancer [48, 49]
Colon cancer [51]
Hepatocellular carcinoma [50]
Atopic dermatitis [53]
 PFDN6   Human   Gastric cancer [35]
Acute lymphocytic leukemia [64]
Arabidopsis thaliana [76] DELLA [67]  
Caenorhabditis elegans FOXO [77]  
α
 PFDN3/VBP1 Anti-oncogene Human VHL [43]
pVHL [44]
hMSH4 [45]
HDAC1 [46]
Gastric cancer [35]
Arabidopsis thaliana DELLA [67]  
Caenorhabditis elegans [66]   
 PFDN5/MM1 Anti-oncogene Human c-Myc [99]
TIF1β [101]
Rabring7 [127]
Egr-1 [128]
ARFP/F [129]
p73α [133]
p63α [134]
ΔNp63α [135]
Gastric cancer [35]
Secondary hyperparathyroidism [54, 55]
Colon cancer [60]
Mouse   Breast cancer [7073]
Arabidopsis thaliana DELLA [67]  
α-like
 URI/Bud27   Human   Cervical cancer [89]
Colon cancer [90]
Gastric cancer [91]
Mouse c-Myc [88] Hepatocellular carcinoma [85]
Yeast Rpb5 [83]
TOR [93]
PFDN6 [94]
 
 UXT/Art-27    NF-κB [95]
Als2 [97]
Androgen receptor [96]
Centrosome component [98]
γ
 γ-prefoldin     Nanobiotechnology [32,33,34]