Fig. 5
From: The functions and mechanisms of prefoldin complex and prefoldin-subunits
Functional domains of human c-Myc protein. a The human c-Myc protein has two main functional domains: the carboxy-terminal domain (CTD) and the amino-terminal domain (NTD). CTD harbors the basic (b) helix–loop–helix (HLH) leucine zipper (LZ). NTD harbors conserved ‘MYC Boxes’ I and II (MBI and MBII). b CTD-interacting proteins: AP2, BRCA1, cdr2, CBF-C, CDC6, Miz-1, MSSPs, Nmi, ORC1, SNF5 and YY-1; NTD-interacting proteins: α-Tubulin, AMY-1, BIN-1, p21, p107, PAM, TBP, and TRRAP. MM-1 is one of the c-Myc NTD-interacting proteins which is bound to the MBII region