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Table 1 The pattern of lincRNA-p21 expression and its roles in various cancers

From: An update on long intergenic noncoding RNA p21: a regulatory molecule with various significant functions in cancer

Cancer type

Sample type

Expression pattern

Gene interplay (Direct or Indirect)

Signaling pathways

Reference

Cell line

Patients

Hepatocellular carcinoma

HepG2 and SMMC-7721 

HCC tumor tissue

Down-regulated

Hes-1, NICD, E-cadherin, and Claudin-1

Notch and EMT signal pathways

[6]

Prostate cancer

LNCaP, DU145, PC3, PTN2 and BPH-1

Prostatectomy specimens

Down-regulated

p53, Mdm2, Puma, Noxa and Bax

P53 Signaling

[7]

Head and neck squamous cell carcinoma

HN4, HN6, HN30 HEK293T, Cal27, SCC25, Detroit562, MCF7, and MDA-MB-231

HNSCC tumor tissues

Down-regulated

p53 and NF-YA

JAK2/STAT3 signaling

[9]

Skin cancer

Balb/MK2 keratinocytes, NHEKs

–

Down-regulated

P53

p53 pathway

[10]

Gastric cancer

MGC-803, MKN-45, BGC-823, MKN-28, SGC-7901 and normal GES-1

GC tissues

Down-regulated

imentin and N-cadherin, YAP, β-catenin and NF-κB, P-ERK

Hippo pathway

[12]

Chronic lymphocytic leukemia

LY-47, BL-60 and BL-7, BJAB, BL-2, and CA-46 

PBMC from patients

Up-regulated after DNA damage

P53, p21

p53 pathway

[13]

Non-small cell lung cancer

H23, H1299, and HCC-44

NSCL tumor tissue

Down-regulated

Secreted vascular endothelial growth factor A (VEGFA)

–

[14]

Colorectal cancer

CRC cell lines HCT-116 (p53þ/þ) and HCT-116 (p53−/−)

CRC specimens

Down-regulated

P53

–

[15]

B cell lymphoma

–

DLBCL tissues

Down-regulated

Cyclin D1, CDK4 and p21

–

[16]

  1. EMT: Epithelial–mesenchymal transition; DLBCL: diffuse large B cell lymphoma; CRC: colorectal cancer; NSCL: non-small cell lung cancer; PBMC: peripheral blood mononuclear cells