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Table 1 The pattern of lincRNA-p21 expression and its roles in various cancers

From: An update on long intergenic noncoding RNA p21: a regulatory molecule with various significant functions in cancer

Cancer typeSample typeExpression patternGene interplay (Direct or Indirect)Signaling pathwaysReference
Cell linePatients
Hepatocellular carcinomaHepG2 and SMMC-7721 HCC tumor tissueDown-regulatedHes-1, NICD, E-cadherin, and Claudin-1Notch and EMT signal pathways[6]
Prostate cancerLNCaP, DU145, PC3, PTN2 and BPH-1Prostatectomy specimensDown-regulatedp53, Mdm2, Puma, Noxa and BaxP53 Signaling[7]
Head and neck squamous cell carcinomaHN4, HN6, HN30 HEK293T, Cal27, SCC25, Detroit562, MCF7, and MDA-MB-231HNSCC tumor tissuesDown-regulatedp53 and NF-YAJAK2/STAT3 signaling[9]
Skin cancerBalb/MK2 keratinocytes, NHEKsDown-regulatedP53p53 pathway[10]
Gastric cancerMGC-803, MKN-45, BGC-823, MKN-28, SGC-7901 and normal GES-1GC tissuesDown-regulatedimentin and N-cadherin, YAP, β-catenin and NF-κB, P-ERKHippo pathway[12]
Chronic lymphocytic leukemiaLY-47, BL-60 and BL-7, BJAB, BL-2, and CA-46 PBMC from patientsUp-regulated after DNA damageP53, p21p53 pathway[13]
Non-small cell lung cancerH23, H1299, and HCC-44NSCL tumor tissueDown-regulatedSecreted vascular endothelial growth factor A (VEGFA)[14]
Colorectal cancerCRC cell lines HCT-116 (p53þ/þ) and HCT-116 (p53−/−)CRC specimensDown-regulatedP53[15]
B cell lymphomaDLBCL tissuesDown-regulatedCyclin D1, CDK4 and p21[16]
  1. EMT: Epithelial–mesenchymal transition; DLBCL: diffuse large B cell lymphoma; CRC: colorectal cancer; NSCL: non-small cell lung cancer; PBMC: peripheral blood mononuclear cells