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Fig. 1 | Cell & Bioscience

Fig. 1

From: An update on long intergenic noncoding RNA p21: a regulatory molecule with various significant functions in cancer

Fig. 1

LincRNA-p21-induced apoptosis via ING1B and p53. MDM2 monoubiquitinates p53, which leads to its degradation by the proteasome complex. Consequently, the apoptosis genes are inhibited and cell survival genes are activated, resulting in the inhibition of apoptosis (up). On the other hand, ING1b leads to the overexpression of lincRNA-p21. Then, lincRNA-p21 binds to MDM2 and detaches it from p53, which results in the increased p53 stability, the induced apoptosis genes, and the suppressed survival cell genes (down)

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