Fig. 1
From: Limited MOMP, ATM, and their roles in carcinogenesis and cancer treatment
(adapted from Liu et al. [19])
A schematic diagram illustrating how limited MOMP facilitates stress induced genetic instability and oncogenic transformation. Left panel shows the conventional scenario where mitochondrial permeability changes leads to activation of Casp3 and leakage of endonuclease G that kills the host cells. Right panel, on the other hand, shows partial leakage and survival of the cells with secondary genetic damage and oncogenic transformation