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Fig. 7 | Cell & Bioscience

Fig. 7

From: Delta opioid peptide [d-Ala2, d-Leu5] enkephalin confers neuroprotection by activating delta opioid receptor-AMPK-autophagy axis against global ischemia

Fig. 7

DOR activation induced protective AMPK/mTOR/ULK1 signaling to enhance autophagy after OGD/R injury. Western blot analysis of p-AMPKα T172 (a), p-mTOR S2448 (b), p-ULK1 S317 (c) and p-ULK1 S757 (d) levels in SH-SY5Y cells (N = 6 per group). The values are shown as the mean ± SEM. Significant differences: the OGD/R group vs. the DADLE group (*p < 0.05) and the naltrindole group (p > 0.05, ns), the DADLE group vs. the DADLE + naltrindole group (**p < 0.01) in a; the OGD/R group vs. the DADLE group (**p < 0.01) and the naltrindole group (p > 0.05, ns), the DADLE group vs. the DADLE + naltrindole group (**p < 0.01) in b; the OGD/R group vs. the DADLE group (***p < 0.001) and the naltrindole group (p > 0.05, ns), the DADLE group vs. the DADLE + naltrindole group (***p < 0.001) in c; the OGD/R group vs. the DADLE group (*p < 0.05) and the naltrindole group (p > 0.05, ns), the DADLE group vs. the DADLE + naltrindole group (***p < 0.001) in d. Nal naltrindole

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