Fig. 6

DOR-induced neuroprotection was AMPK-dependent in ischemic CA1 neurons. a Representative images of neurons labeled with NeuN. Obvious improvement in neuronal survival was observed in the DADLE group and A769662 group compared with the I/R group, while severe neuronal injury was observed in the compound C group. Obvious neuronal loss was observed in the DADLE + compound C group compared to the DADLE group. Scale bar = 100 μm. b Quantitative analysis of neuron counts (N = 3 per group). The values are shown as the mean ± SEM. Significant differences: the I/R group vs. the DADLE group (*p < 0.05), the A769662 group (**p < 0.01) and the compound C group (***p < 0.001), the DADLE group vs. the DADLE + compound C group (***p < 0.001) and the A769662 group (p > 0.05, ns) in b. DAD: DADLE