Skip to main content
Fig. 4 | Cell & Bioscience

Fig. 4

From: Identification of hub genes associated with RNAi-induced silencing of XIAP through targeted proteomics approach in MCF7 cells

Fig. 4

Functional classification of DEPs in MCF-7 cells exposed to RNAi-induced silencing of XIAP. a A network of protein–protein interaction among the XIAP-regulated proteins was constructed. XIAP did not directly interact with the identified DEPs in MCF-7 cells. According to the textmining criteria, XIAP interacts with HSP90B1, HSPB1, and ALB. b The molecular function of the XIAP-regulated proteins are demonstrated. The precise mechanism of action of XIAP with the DEPs was not identified yet. Colors and shapes of line show binding (blue), reaction (black), catalysis (indigo), activation (light green), post-translational modification (fuchsia). The positive and negative effects were illustrated by arrowhead and bar, respectively. c Network of regulated proteins by XIAP was constructed according to the degree, betweenness centrality, and co-expression by CytoHubba application in Cytoscape software. The thickness of grey lines indicates the strength of co-expression. HSP90AA1 and HSPA6 were identified as the hub genes in this network. Although, it should not be ignored the impact of HSPA8 and ENO1 genes

Back to article page