From: MicroRNA-7: expression and function in brain physiological and pathological processes
Targets | Brain regions | Expression | Effects | Refs. |
---|---|---|---|---|
PTGFRN | Pituitary gland | Downregulation | lower level of PTGFR and LH release; the decrease of uterine contraction, ovulation, embryo implantation and other vital reproductive processes | [20] |
GLG1, BMP4 | Pituitary gland | Downregulation | The lower secretion of PTGFRN, FSH and LH | [37] |
Notch effector | Optic nerve epithelial cells | Downregulation | The more stable transformation of neuroepithelial cells to neuroblastocytes | [39] |
Yan | Visual progenitor cell | Downregulation | The inhibition of miR-7 transcription, ensure that photoreceptors are successfully and accurately differentiated | [42] |
PAX6 | Eye and brain | Downregulation | The maintenance of ocular development and formation | [43] |
Ak1, Cdkn1a | Embryo cortical | Upregulation | Decreased production of cortical progenitor cells during brain development | [45] |
GLI3 | Embryonic cortex | Loss | The increased proportion of neural progenitor cells and newborn neurons in the brain, which resulting in the brain enlargement after birth and the abnormal folding structure of cortical midline | [46] |
Sepp, NR4A3 | Hippocampus | Loss | Deficience in the synaptic plasticity in the hippocampus | |
α-syn | Substantia nigra | Upregulation | Increased neurons from oxidative stress and proteasomal damage, | [23] |
SNCA | Substantia nigra | Upregulation | The increased expression of α-syn | [54] |
mTOR | Substantia nigra | Downregulation | Protecting the neuron cells damage | [60] |
SHANK3 | Cerebral cortex | Downregulation | Deficience in synaptic plasticity and relation with memory and learning | [66] |
Herpud2 | Brain tissue | Upregulation | Brake on neuroinflammation | [68] |
TLR4 | Microglia | Downregulation | Block of brain microglia activation, cytokine production and slow the secondary damage of brain tissue | [69] |
RORα | Neuron | Downregulation | aggravated pathology of brain tissue inflammation | [70] |