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Table 1 The effects of miR-7 target in physiological and pathological processes of brain

From: MicroRNA-7: expression and function in brain physiological and pathological processes

Targets

Brain regions

Expression

Effects

Refs.

PTGFRN

Pituitary gland

Downregulation

lower level of PTGFR and LH release; the decrease of uterine contraction, ovulation, embryo implantation and other vital reproductive processes

[20]

GLG1, BMP4

Pituitary gland

Downregulation

The lower secretion of PTGFRN, FSH and LH

[37]

Notch effector

Optic nerve epithelial cells

Downregulation

The more stable transformation of neuroepithelial cells to neuroblastocytes

[39]

Yan

Visual progenitor cell

Downregulation

The inhibition of miR-7 transcription, ensure that photoreceptors are successfully and accurately differentiated

[42]

PAX6

Eye and brain

Downregulation

The maintenance of ocular development and formation

[43]

Ak1, Cdkn1a

Embryo cortical

Upregulation

Decreased production of cortical progenitor cells during brain development

[45]

GLI3

Embryonic cortex

Loss

The increased proportion of neural progenitor cells and newborn neurons in the brain, which resulting in the brain enlargement after birth and the abnormal folding structure of cortical midline

[46]

Sepp, NR4A3

Hippocampus

Loss

Deficience in the synaptic plasticity in the hippocampus

[48, 49]

α-syn

Substantia nigra

Upregulation

Increased neurons from oxidative stress and proteasomal damage,

[23]

SNCA

Substantia nigra

Upregulation

The increased expression of α-syn

[54]

mTOR

Substantia nigra

Downregulation

Protecting the neuron cells damage

[60]

SHANK3

Cerebral cortex

Downregulation

Deficience in synaptic plasticity and relation with memory and learning

[66]

Herpud2

Brain tissue

Upregulation

Brake on neuroinflammation

[68]

TLR4

Microglia

Downregulation

Block of brain microglia activation, cytokine production and slow the secondary damage of brain tissue

[69]

RORα

Neuron

Downregulation

aggravated pathology of brain tissue inflammation

[70]

  1. PTGFRN Prostaglandin F2 receptor negative regulator; PTGFR prostaglandin F2 receptor; LH luteinizing hormone; GLG1 golgi glycoprotein 1; BMP4 bone morphogenetic protein 4; FSH follicle-stimulating hormone; PAX6 paired box 6; AK1 adenylate kinase 1; Cdkn1a cyclin dependent kinase inhibitor 1a; GLI3 GLI family zinc finger 3; Sepp selenoprotein P; NR4A3 Nuclear Receptor Subfamily 4 Group A Member 3; α-syn α-synuclein; SNCA synuclein alpha; SHANK3 SH3 and multiple ankyrin repeat 3 domains